Detecting multiple, simultaneous talkers through localising speech recorded by ad-hoc microphone arrays

This paper proposes a novel approach to detecting multiple, simultaneous talkers in multi-party meetings using localisation of active speech sources recorded with an ad-hoc microphone array. Cues indicating the relative distance between sources and microphones are derived from speech signals and room impulse responses recorded by each of the microphones distributed at unknown locations within a room. Multiple active sources are localised by analysing a surface formed from these cues and derived at different locations within the room. The number of localised active sources per each frame or utterance is then counted to estimate when multiple sources are active. The proposed approach does not require prior information about the number and locations of sources or microphones. Synchronisation between microphones is also not required. A meeting scenario with competing speakers is simulated and results show that simultaneously active sources can be detected with an average accuracy of 75% and the number of active sources counted accurately 65% of the time

Spatialized teleconferencing: recording and \u27Squeezed\u27 rendering of multiple distributed sites

Teleconferencing systems are becoming increasing realistic and pleasant for users to interact with geographically distant meeting participants. Video screens display a complete view of the remote participants, using technology such as wraparound or multiple video screens. However, the corresponding audio does not offer the same sophistication: often only a mono or stereo track is presented. This paper proposes a teleconferencing audio recording and playback paradigm that captures the spatial location of the geographically distributed participants for rendering of the remote soundfields at the users\u27 end. Utilizing standard 5.1 surround sound playback, this paper proposes a surround rendering approach that `squeezes\u27 the multiple recorded soundfields from remote teleconferencing sites to assist the user to disambiguate multiple speakers from different participating sites

An efficient approach to dynamically weighted multizone wideband reproduction of speech soundfields

This paper proposes and evaluates an efficient approach for practical reproduction of multizone soundfields for speech sources. The reproduction method, based on a previously proposed approach, utilises weighting parameters to control the soundfield reproduced in each zone whilst minimising the number of loudspeakers required. Proposed here is an interpolation scheme for predicting the weighting parameter values of the multizone soundfield model that otherwise requires significant computational effort. It is shown that initial computation time can be reduced by a factor of 1024 with only 85dB of error in the reproduced soundfield relative to reproduction without interpolated weighting parameters. The perceptual impact on the quality of the speech reproduced using the method is also shown to be negligible. By using pre-saved soundfields determined using the proposed approach, practical reproduction of dynamically weighted multizone soundfields of wideband speech could be achieved in real-time

3D Modelling and Printing of Microtonal Flutes

This project explores the potential for 3D modelling and printing to create customised flutes that can play music in a variety of microtonal scales. One of the challenges in the field of microtonality is that conventional musical instruments are inadequate for realising the abundance of theoretical tunings that musicians wish to investigate. This paper focuses on the development of two types of flutes, the recorder and transverse flute, with interchangeable mouthpieces. These flutes are designed to play subharmonic microtonal scales. The discussion provides an overview of the design and implementation process, including calculation methods for acoustic modelling and 3D printing technologies, as well as an evaluation of some of the difficulties encountered. Results from our 3D printed flutes suggest that whilst further refinements are necessary in our designs, 3D modelling and printing techniques offer new and valuable methods for the design and production of customised musical instruments. The long term goal of this project is to create a system in which users can specify the tuning of their instrument to generate a 3D model and have it printed on demand

Backward Compatible Spatialized Teleconferencing based on Squeezed Recordings

Commercial teleconferencing systems currently available, although offering sophisticated video stimulus of the remote participants, commonly employ only mono or stereo audio playback for the user. However, in teleconferencing applications where there are multiple participants at multiple sites, spatializing the audio reproduced at each site (using headphones or loudspeakers) to assist listeners to distinguish between participating speakers can significantly improve the meeting experience (Baldis, 2001; Evans et al., 2000; Ward & Elko 1999; Kilgore et al., 2003; Wrigley et al., 2009; James & Hawksford, 2008). An example is Vocal Village (Kilgore et al., 2003), which uses online avatars to co-locate remote participants over the Internet in virtual space with audio spatialized over headphones (Kilgore, et al., 2003). This system adds speaker location cues to monaural speech to create a user manipulable soundfield that matches the avatar’s position in the virtual space. Giving participants the freedom to manipulate the acoustic location of other participants in the rendered sound scene that they experience has been shown to provide for improved multitasking performance (Wrigley et al., 2009). A system for multiparty teleconferencing requires firstly a stage for recording speech from multiple participants at each site. These signals then need to be compressed to allow for efficient transmission of the spatial speech. One approach is to utilise close-talking microphones to record each participant (e.g. lapel microphones), and then encode each speech signal separately prior to transmission (James & Hawksford, 2008). Alternatively, for increased flexibility, a microphone array located at a central point on, say, a meeting table can be used to generate a multichannel recording of the meeting speech A microphone array approach is adopted in this work and allows for processing of the recordings to identify relative spatial locations of the sources as well as multichannel speech enhancement techniques to improve the quality of recordings in noisy environments. For efficient transmission of the recorded signals, the approach also requires a multichannel compression technique suitable to spatially recorded speech signals

Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and e status and the degree of inflammation: a post hoc analysis of a randomized intervention trial

Abstract Background Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. Methods Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [− 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We therefore sought to identify transcriptional signatures in whole blood of Indian children, capable of discriminating intra-thoracic TB disease from other symptomatic illnesses. We investigated the expression of 198 genes in a training set, comprising 47 TB cases (19 definite/28 probable) and 36 asymptomatic household controls, and identified a 7- and a 10-transcript signature, both including NOD2, GBP5, IFITM1/3, KIF1B and TNIP1. The discriminatory abilities of the signatures were evaluated in a test set comprising 24 TB cases (17 definite/7 probable) and 26 symptomatic non-TB cases. In separating TB-cases from symptomatic non-TB cases, both signatures provided an AUC of 0.94 (95%CI, 0.88–1.00), a sensitivity of 91.7% (95%CI, 71.5–98.5) regardless of culture status, and 100% sensitivity for definite TB. The 7-transcript signature provided a specificity of 80.8% (95%CI, 60.0–92.7), and the 10-transcript signature a specificity of 88.5% (95%CI, 68.7–96.9%). Although warranting exploration and validation in other populations, our findings are promising and potentially relevant for future non-sputum based POC diagnostic tools for pediatric TB.publishedVersio

BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome

Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification of patients with treatment failure. Therefore, in a cohort of 99 Indian children with intrathoracic tuberculosis (TB), we performed blood transcriptome kinetic analysis during ATT to explore 1) the association between transcriptional biomarkers in whole blood (WB) and the extent of TB disease at diagnosis and treatment outcomes at 2 and 6 months, and 2) the potential of the biomarkers to predict treatment response at 2 and 6 months. We present the first data on the association between transcriptional biomarkers and the extent of TB disease as well as outcome of ATT in children: Expression of three genes down-regulated on ATT (FCGR1A, FPR1 and MMP9) exhibited a positive correlation with the extent of TB disease, whereas expression of eight up-regulated genes (BCL, BLR1, CASP8, CD3E, CD4, CD19, IL7R and TGFBR2) exhibited a negative correlation with the extent of disease. Baseline levels of these transcripts displayed an individual capacity >70% to predict the six-month treatment outcome. In particular, BLR1 and FCGR1A seem to have a potential in monitoring and perhaps tailoring future antituberculosis therapy

Pregnant women with bronchial asthma benefit from progressive muscle relaxation: A randomized, prospective, controlled trial

Background: Asthma is a serious medical problem in pregnancy and is often associated with stress, anger and poor quality of life. The aim of this study was to determine the efficacy of progressive muscle relaxation (PMR) on change in blood pressure, lung parameters, heart rate, anger and health-related quality of life in pregnant women with bronchial asthma. Methods: We treated a sample of 64 pregnant women with bronchial asthma from the local population in an 8-week randomized, prospective, controlled trial. Thirty-two were selected for PMR, and 32 received a placebo intervention. The systolic blood pressure, forced expiratory volume in the first second, peak expiratory flow and heart rate were tested, and the State-Trait Anger Expression Inventory and Health Survey (SF-36) were employed. Results: According to the intend-to-treat principle, a significant reduction in systolic blood pressure and a significant increase in both forced expiratory volume in the first second and peak expiratory flow were observed after PMR. The heart rate showed a significant increase in the coefficient of variation, root mean square of successive differences and high frequency ranges, in addition to a significant reduction in low and middle frequency ranges. A significant reduction on three of five State-Trait Anger Expression Inventory scales, and a significant increase on seven of eight SF-36 scales were observed. Conclusions: PMR appears to be an effective method to improve blood pressure, lung parameters and heart rate, and to decrease anger levels, thus enhancing health-related quality of life in pregnant women with bronchial asthma. Copyright (c) 2006 S. Karger AG, Basel

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes

CITATION: Sivakumaran, Dhanasekaran et al. 2020. Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes. Communications Biology, 3(1):359, doi:10.1038/s42003-020-1087-x.The original publication is available at: https://pubmed.ncbi.nlm.nih.gov/Tuberculosis (TB) is a global health concern. Treatment is prolonged, and patients on anti-TB therapy (ATT) often experience treatment failure for various reasons. There is an urgent need to identify signatures for early detection of failure and initiation of a treatment switch.We investigated how gene biomarkers and/or basic patient characteristics could be used to define signatures for treatment outcomes in Indian adult pulmonary-TB patients treated with standard ATT. Using blood samples at baseline, a 12-gene signature combined with information on gender, previously-diagnosed TB, severe thinness, smoking and alcohol consumption was highly predictive of treatment failure at 6 months. Likewise a 4-protein biomarker signature combined with the same patient characteristics was almost as highly predictive of treatment failure. Combining biomarkers and basic patient characteristics may be useful for predicting and hence identification of treatment failure at an early stage of TB therapy.Publlisher's versio